Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG430

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e9ee051e-6dfb-5d22-a0e2-e9eb2d07fbc9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • TGF_BETA_SIGNALING+0.373
  • INTERFERON_ALPHA_RESPONSE+0.339
  • UV_RESPONSE_DN+0.333
  • HEME_METABOLISM+0.328
  • PROTEIN_SECRETION+0.280
  • WNT_BETA_CATENIN_SIGNALING+0.254
  • MITOTIC_SPINDLE+0.215
  • PEROXISOME+0.191
  • INTERFERON_GAMMA_RESPONSE+0.172
  • PI3K_AKT_MTOR_SIGNALING+0.167

Top 10 suppressed

  • TNFA_SIGNALING_VIA_NFKB-0.450
  • MYC_TARGETS_V2-0.434
  • ANGIOGENESIS-0.427
  • MTORC1_SIGNALING-0.360
  • PANCREAS_BETA_CELLS-0.333
  • ESTROGEN_RESPONSE_LATE-0.298
  • HYPOXIA-0.294
  • CHOLESTEROL_HOMEOSTASIS-0.279
  • UV_RESPONSE_UP-0.261
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.241

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG633
mng-umap@100
——0.858
2MNG442
mng-umap@100
——0.808
3MNG997
mng-umap@100
——0.807
4MNG671
mng-umap@100
——0.776
5MNG881
mng-umap@100
——0.775
6MNG310
mng-umap@100
——0.752
7MNG876
mng-umap@100
——0.724
8MNG776
mng-umap@100
——0.723
9MNG451
mng-umap@100
——0.722
10MNG396
mng-umap@100
——0.721

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TGF_BETA_SIGNALING0.373Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.339Inavolisib— uncovered
UV_RESPONSE_DN0.333Inavolisib— uncovered
HEME_METABOLISM0.328Temsirolimus— uncovered
PROTEIN_SECRETION0.280Remibrutinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.254Inavolisib— uncovered
MITOTIC_SPINDLE0.215Inavolisib— uncovered
PEROXISOME0.191Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.172Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.167Inavolisib— uncovered
ALLOGRAFT_REJECTION0.146Idelalisib— uncovered
APICAL_SURFACE0.141Temsirolimus— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.138Inavolisib— uncovered
APICAL_JUNCTION0.108Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.099Remibrutinib— uncovered
ADIPOGENESIS0.076Inavolisib— uncovered
FATTY_ACID_METABOLISM0.055Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.012Inavolisib— uncovered
MYC_TARGETS_V10.009Inavolisib— uncovered
NOTCH_SIGNALING0.002Inavolisib— uncovered