MBCProject_6876_T1_RNA
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.320
- E2F_TARGETS+0.310
- DNA_REPAIR+0.190
- ESTROGEN_RESPONSE_EARLY+0.190
- G2M_CHECKPOINT+0.150
- CHOLESTEROL_HOMEOSTASIS+0.100
- WNT_BETA_CATENIN_SIGNALING+0.090
- PEROXISOME+0.040
- ESTROGEN_RESPONSE_LATE+0.030
- INTERFERON_ALPHA_RESPONSE+0.000
Top 10 suppressed
- UV_RESPONSE_DN-0.360
- KRAS_SIGNALING_UP-0.330
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.320
- ANDROGEN_RESPONSE-0.310
- HYPOXIA-0.300
- PROTEIN_SECRETION-0.300
- INFLAMMATORY_RESPONSE-0.280
- TGF_BETA_SIGNALING-0.280
- TNFA_SIGNALING_VIA_NFKB-0.280
- ANGIOGENESIS-0.260
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-E9-A3HO-01A-11R-A213-07 | — | B | 0.813 |
| 2 | MBCProject_0381_T1_RNA | — | B | 0.812 |
| 3 | TCGA-E2-A15O-01A-11R-A115-07 | — | B | 0.811 |
| 4 | SRR8942965 | — | — | 0.811 |
| 5 | MNG1109 | — | — | 0.805 |
| 6 | SRR1797263 | — | cohortSC | 0.797 |
| 7 | c01b5135.b754.4c57.a81d.68a951803fab | — | cohortMD1 | 0.796 |
| 8 | SRR2932832 | — | — | 0.784 |
| 9 | SRR8526719 | — | cohortMD1 | 0.783 |
| 10 | SRR1313143 | — | E | 0.782 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.320 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.310 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.190 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.190 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.150 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.100 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.090 | Inavolisib | — uncovered |
| PEROXISOME | 0.040 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.030 | Idelalisib | — uncovered |