MBCProject_0381_T1_RNA
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.320
- G2M_CHECKPOINT+0.220
- E2F_TARGETS+0.200
- MITOTIC_SPINDLE+0.070
- GLYCOLYSIS-0.010
- DNA_REPAIR-0.020
- ESTROGEN_RESPONSE_EARLY-0.020
- ESTROGEN_RESPONSE_LATE-0.070
- MYC_TARGETS_V1-0.120
- UNFOLDED_PROTEIN_RESPONSE-0.120
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.550
- INTERFERON_GAMMA_RESPONSE-0.530
- COMPLEMENT-0.520
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.520
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.510
- ANGIOGENESIS-0.490
- COAGULATION-0.470
- IL6_JAK_STAT3_SIGNALING-0.470
- INFLAMMATORY_RESPONSE-0.460
- TGF_BETA_SIGNALING-0.450
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_D0RDN4K5 | Embryonal tumors | — | 0.936 |
| 2 | SAMN03290905 | — | — | 0.934 |
| 3 | BS_A87NPZAP | medulloblastoma | — | 0.927 |
| 4 | BS_1BWP5MCT | medulloblastoma | — | 0.923 |
| 5 | BS_4W68NV3M | medulloblastoma | — | 0.920 |
| 6 | SRR8518343 | — | E | 0.918 |
| 7 | SRR650166 | — | — | 0.916 |
| 8 | BS_3NWQXPQV | medulloblastoma | — | 0.912 |
| 9 | c01b5135.b754.4c57.a81d.68a951803fab | — | cohortMD1 | 0.910 |
| 10 | SRR1324452 | GTEX | — | 0.904 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.320 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.220 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.200 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.070 | Inavolisib | — uncovered |