SRR650166
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.240
- SPERMATOGENESIS+0.210
- MYC_TARGETS_V2+0.200
- E2F_TARGETS-0.050
- WNT_BETA_CATENIN_SIGNALING-0.070
- G2M_CHECKPOINT-0.090
- MITOTIC_SPINDLE-0.140
- PANCREAS_BETA_CELLS-0.150
- DNA_REPAIR-0.170
- APICAL_SURFACE-0.180
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.620
- INTERFERON_GAMMA_RESPONSE-0.580
- IL6_JAK_STAT3_SIGNALING-0.570
- ALLOGRAFT_REJECTION-0.540
- COMPLEMENT-0.540
- ANDROGEN_RESPONSE-0.530
- ANGIOGENESIS-0.530
- INFLAMMATORY_RESPONSE-0.530
- PROTEIN_SECRETION-0.510
- CHOLESTEROL_HOMEOSTASIS-0.500
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_4W68NV3M | medulloblastoma | — | 0.955 |
| 2 | SRR1433644 | GTEX | — | 0.955 |
| 3 | SRR1439850 | GTEX | — | 0.951 |
| 4 | SRR1467813 | GTEX | — | 0.950 |
| 5 | TCGA-KQ-A41O-01A-12R-A352-07 | — | — | 0.950 |
| 6 | SRR650150 | — | — | 0.945 |
| 7 | BS_1BWP5MCT | Med | Medulloblastoma | 0.945 |
| 8 | SRR1338669 | GTEX | — | 0.945 |
| 9 | SRR1348021 | GTEX | — | 0.944 |
| 10 | SRR1328960 | GTEX | — | 0.943 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 3 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.240 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.210 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.200 | Idelalisib | — uncovered |