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TCGA-77-A5G3-01A-31R-A27Q-07

· cohortSQ2

51621627-1c4d-5a7d-b65a-f40107e157ba

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortSQ2
subtype
cohortSQ2
age_years
63

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-56-7823-01B-11R-2247-07
lung-landscapes@6
cohortSQ20.915
2C3N-04155
lung-landscapes@6
cohortSQ20.896
3TCGA-85-8580-01A-31R-2403-07
lung-landscapes@6
cohortSQ20.891
4SRR934765
brain-umap@2
0.883
5TCGA-22-5477-01A-01R-1635-07
lung-landscapes@6
cohortSQ20.879
6TCGA-A8-A07L-01A-11R-A00Z-07
breast-umap@18
B0.877
7TCGA-77-8153-01A-11R-2403-07
lung-landscapes@6
cohortSQ20.877
8TCGA-J1-A4AH-01A-31R-A24H-07
lung-landscapes@6
cohortSQ20.875
9SRR9879288
lung-landscapes@6
cohortSQ20.874
10MDT-AP-0513
medullo-epn-umap@date-based
MedMedulloblastoma0.873

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 17 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.580Idelalisib— uncovered
G2M_CHECKPOINT0.540Inavolisib— uncovered
E2F_TARGETS0.530Inavolisib— uncovered
MYC_TARGETS_V10.470Inavolisib— uncovered
MITOTIC_SPINDLE0.400Inavolisib— uncovered
HEDGEHOG_SIGNALING0.390Inavolisib— uncovered
MTORC1_SIGNALING0.300Inavolisib— uncovered
DNA_REPAIR0.280Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.260Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.250Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.180Idelalisib— uncovered
APICAL_SURFACE0.130Temsirolimus— uncovered
PI3K_AKT_MTOR_SIGNALING0.110Inavolisib— uncovered
UV_RESPONSE_UP0.090Idelalisib— uncovered
P53_PATHWAY0.070Idelalisib— uncovered
UV_RESPONSE_DN0.050Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.040Idelalisib— uncovered