Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1097392

GTEX

517cda22-3a41-54d4-927a-353e8b31e394

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • SPERMATOGENESIS+0.200
  • UNFOLDED_PROTEIN_RESPONSE+0.197
  • DNA_REPAIR+0.190
  • OXIDATIVE_PHOSPHORYLATION+0.184
  • PROTEIN_SECRETION+0.178
  • MYC_TARGETS_V1+0.143
  • MYC_TARGETS_V2+0.074
  • PEROXISOME+0.041
  • MITOTIC_SPINDLE+0.035
  • PI3K_AKT_MTOR_SIGNALING+0.034

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.603
  • INTERFERON_GAMMA_RESPONSE-0.534
  • TNFA_SIGNALING_VIA_NFKB-0.529
  • IL6_JAK_STAT3_SIGNALING-0.521
  • INFLAMMATORY_RESPONSE-0.511
  • ALLOGRAFT_REJECTION-0.462
  • TGF_BETA_SIGNALING-0.425
  • COAGULATION-0.423
  • KRAS_SIGNALING_UP-0.423
  • ANGIOGENESIS-0.416

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1451897
brain-umap@2
GTEX0.981
2SRR1410934
brain-umap@2
GTEX0.980
3SRR1500537
brain-umap@2
GTEX0.980
4SRR1374246
brain-umap@2
GTEX0.980
5SRR1315842
brain-umap@2
GTEX0.980
6SRR1393068
brain-umap@2
GTEX0.979
7SRR1429891
brain-umap@2
GTEX0.978
8SRR1405224
brain-umap@2
GTEX0.978
9SRR1441118
brain-umap@2
GTEX0.977
10SRR1441141
brain-umap@2
GTEX0.977

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 10 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
SPERMATOGENESIS0.200Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.197Idelalisib— uncovered
DNA_REPAIR0.190Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.184Remibrutinib— uncovered
PROTEIN_SECRETION0.178Remibrutinib— uncovered
MYC_TARGETS_V10.143Inavolisib— uncovered
MYC_TARGETS_V20.074Idelalisib— uncovered
PEROXISOME0.041Idelalisib— uncovered
MITOTIC_SPINDLE0.035Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.034Inavolisib— uncovered