SRR1316535
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.359
- KRAS_SIGNALING_DN+0.286
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.156
- COAGULATION+0.122
- HEDGEHOG_SIGNALING+0.121
- APICAL_SURFACE+0.111
- XENOBIOTIC_METABOLISM+0.084
- SPERMATOGENESIS+0.080
- CHOLESTEROL_HOMEOSTASIS+0.067
- MYOGENESIS+0.047
Top 10 suppressed
- TGF_BETA_SIGNALING-0.500
- G2M_CHECKPOINT-0.498
- MITOTIC_SPINDLE-0.474
- E2F_TARGETS-0.454
- PROTEIN_SECRETION-0.452
- MYC_TARGETS_V1-0.440
- UV_RESPONSE_DN-0.409
- ANDROGEN_RESPONSE-0.391
- INTERFERON_ALPHA_RESPONSE-0.368
- INTERFERON_GAMMA_RESPONSE-0.316
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | d2c9b21d-0f64-4182-9d5d-82b80a158a1f | — | — | 0.923 |
| 2 | MDT-AP-2026 | Med | Medulloblastoma | 0.899 |
| 3 | SJEPD001534_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.895 |
| 4 | 12183b9e-ecf0-4eaa-9422-157dfa09a66b | — | — | 0.892 |
| 5 | SRR1316921 | GTEX | — | 0.882 |
| 6 | SRR8613724 | — | F | 0.870 |
| 7 | SRR13311177 | — | — | 0.866 |
| 8 | 52425995-0bd7-4149-bc2a-26522ebd143d | — | — | 0.864 |
| 9 | SRR1444460 | GTEX | — | 0.863 |
| 10 | SRR1356036 | GTEX | — | 0.862 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.359 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.286 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.156 | Inavolisib | — uncovered |
| COAGULATION | 0.122 | Binimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.121 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.111 | Temsirolimus | — uncovered |
| XENOBIOTIC_METABOLISM | 0.084 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.080 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.067 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.047 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.022 | Idelalisib | — uncovered |
| APICAL_JUNCTION | 0.020 | Inavolisib | — uncovered |
| PEROXISOME | 0.012 | Idelalisib | — uncovered |