MDT-AP-3296
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- age_years
- 6.6
- sex
- M
- new_clusters
- C6
- umap1_2d
- 3.180211552
- umap2_2d
- 6.387232866
- umap1_3d
- 2.29624916
- umap2_3d
- -1.133202216
- umap3_3d
- -4.838788853
- dataset
- Med-Taylor
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-A7-A13G-01A-11R-A13Q-07 | — | D | 0.901 |
| 2 | MDT-AP-0119 | Med | Medulloblastoma | 0.886 |
| 3 | MDT-AP-3246 | Med | Medulloblastoma | 0.878 |
| 4 | MDT-AP-3207 | Med | Medulloblastoma | 0.871 |
| 5 | MDT-AP-3253 | Med | Medulloblastoma | 0.871 |
| 6 | TCGA-BL-A0C8-01B-04R-A277-07 | — | — | 0.869 |
| 7 | MDT-AP-0189 | Med | Medulloblastoma | 0.865 |
| 8 | MDT-AP-3290 | Med | Medulloblastoma | 0.863 |
| 9 | BS_HTEPAKCM | Med | Medulloblastoma | 0.854 |
| 10 | MNG45 | — | — | 0.850 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.420 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.150 | Temsirolimus | — uncovered |
| HEDGEHOG_SIGNALING | 0.140 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.140 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.120 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.100 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.070 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.070 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.060 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.020 | Idelalisib | — uncovered |