MNG45
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.250
- NOTCH_SIGNALING+0.181
- UV_RESPONSE_DN+0.038
- BILE_ACID_METABOLISM+0.022
- HEME_METABOLISM+0.017
- MYC_TARGETS_V2-0.013
- MITOTIC_SPINDLE-0.046
- PEROXISOME-0.049
- APICAL_SURFACE-0.051
- SPERMATOGENESIS-0.056
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.482
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.444
- TNFA_SIGNALING_VIA_NFKB-0.441
- IL6_JAK_STAT3_SIGNALING-0.438
- ALLOGRAFT_REJECTION-0.426
- INTERFERON_GAMMA_RESPONSE-0.420
- INFLAMMATORY_RESPONSE-0.409
- HYPOXIA-0.366
- APOPTOSIS-0.352
- P53_PATHWAY-0.346
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-0189 | Med | Medulloblastoma | 0.903 |
| 2 | SRR650167 | — | — | 0.890 |
| 3 | SRR650132 | — | — | 0.888 |
| 4 | SRR8613727 | — | D | 0.885 |
| 5 | SRR607967 | GTEX | — | 0.884 |
| 6 | SRR8518450 | — | A | 0.884 |
| 7 | SRR1399904 | GTEX | — | 0.884 |
| 8 | TCGA-A7-A0DC-01A-11R-A00Z-07 | — | D | 0.883 |
| 9 | TCGA-OR-A5LB-01 | Adrenocortical Carcinoma | Adrenocortical Carcinoma, Usual Type | 0.881 |
| 10 | SRR657325 | GTEX | — | 0.879 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.250 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.181 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.038 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.022 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.017 | Temsirolimus | — uncovered |