BS_A87NPZAP
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- os_event
- false
- age_years
- 13.471
- sex
- F
- race
- White
- new_clusters
- C6
- umap1_2d
- 5.156902441
- umap2_2d
- 6.963116002
- umap1_3d
- 3.567846102
- umap2_3d
- -1.002628137
- umap3_3d
- -4.127413651
- dataset
- Med-CBTN
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1313120 | — | A | 0.889 |
| 2 | MNG656 | — | — | 0.887 |
| 3 | BS_V7BJM89K | low-grade glioma | — | 0.878 |
| 4 | SRR1313097 | — | A | 0.875 |
| 5 | MDT-AP-0373 | Med | Medulloblastoma | 0.871 |
| 6 | MDT-AP-0734 | Med | Medulloblastoma | 0.867 |
| 7 | MDT-AP-0830 | Med | Medulloblastoma | 0.866 |
| 8 | TCGA-D8-A3Z5-01A-41R-A24H-07 | — | A | 0.863 |
| 9 | SRR1313093 | — | B | 0.860 |
| 10 | SRR1313099 | — | A | 0.854 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| NOTCH_SIGNALING | 0.180 | Inavolisib | — uncovered |
| MYOGENESIS | 0.100 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.060 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.040 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.040 | Remibrutinib | — uncovered |
| APICAL_SURFACE | 0.020 | Temsirolimus | — uncovered |
| P53_PATHWAY | 0.010 | Idelalisib | — uncovered |