SRR8942980
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- TGF_BETA_SIGNALING+0.400
- PROTEIN_SECRETION+0.250
- PANCREAS_BETA_CELLS+0.070
- UV_RESPONSE_DN+0.040
- WNT_BETA_CATENIN_SIGNALING+0.000
- HEME_METABOLISM-0.050
- P53_PATHWAY-0.090
- BILE_ACID_METABOLISM-0.100
- NOTCH_SIGNALING-0.110
- ANDROGEN_RESPONSE-0.120
Top 10 suppressed
- E2F_TARGETS-0.540
- IL6_JAK_STAT3_SIGNALING-0.530
- ALLOGRAFT_REJECTION-0.510
- G2M_CHECKPOINT-0.490
- INTERFERON_GAMMA_RESPONSE-0.470
- INFLAMMATORY_RESPONSE-0.460
- INTERFERON_ALPHA_RESPONSE-0.460
- MYC_TARGETS_V2-0.440
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.430
- APICAL_SURFACE-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR23303736 | — | — | 0.914 |
| 2 | SRR1516063 | — | — | 0.910 |
| 3 | SRR1516060 | — | — | 0.910 |
| 4 | SRR1516046 | — | — | 0.909 |
| 5 | SRR12475149 | — | — | 0.907 |
| 6 | C3N-03420 | — | cohortA1 | 0.905 |
| 7 | SRR8943008 | — | — | 0.893 |
| 8 | R247 | — | — | 0.888 |
| 9 | MDT-AP-2991 | Med | Medulloblastoma | 0.883 |
| 10 | SRR1516058 | — | — | 0.880 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| TGF_BETA_SIGNALING | 0.400 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.250 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.070 | Cobimetinib | — uncovered |
| UV_RESPONSE_DN | 0.040 | Inavolisib | — uncovered |