eb67b977-b299-4bbc-b3f6-25d516473405
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 54
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.160
- HEME_METABOLISM+0.110
- BILE_ACID_METABOLISM+0.090
- FATTY_ACID_METABOLISM+0.080
- PANCREAS_BETA_CELLS+0.070
- WNT_BETA_CATENIN_SIGNALING+0.060
- P53_PATHWAY+0.040
- SPERMATOGENESIS+0.010
- GLYCOLYSIS-0.010
- PEROXISOME-0.010
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.610
- ALLOGRAFT_REJECTION-0.540
- IL6_JAK_STAT3_SIGNALING-0.460
- INTERFERON_GAMMA_RESPONSE-0.460
- MTORC1_SIGNALING-0.460
- E2F_TARGETS-0.450
- INFLAMMATORY_RESPONSE-0.440
- G2M_CHECKPOINT-0.420
- TNFA_SIGNALING_VIA_NFKB-0.420
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.390
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12475149 | — | — | 0.913 |
| 2 | SRR1516067 | — | — | 0.907 |
| 3 | C3N-03420 | — | cohortA1 | 0.899 |
| 4 | TCGA-MP-A5C7-01A-11R-A262-07 | — | cohortA2 | 0.891 |
| 5 | 50f58d2f-7e67-40d8-a35c-a3e2c0bbe457 | — | — | 0.888 |
| 6 | SRR1516063 | — | — | 0.888 |
| 7 | SRR1516072 | — | — | 0.887 |
| 8 | TCGA-CF-A5U8-01A-11R-A28M-07 | — | — | 0.886 |
| 9 | TCGA-G2-A3IE-01A-11R-A20F-07 | — | — | 0.884 |
| 10 | TCGA-E7-A6MF-01A-12R-A32O-07 | — | — | 0.883 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.160 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.110 | Temsirolimus | — uncovered |
| BILE_ACID_METABOLISM | 0.090 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.080 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.070 | Cobimetinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.060 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.040 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.010 | Inavolisib | — uncovered |