ERR2598198
fetal · fetal
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- fetal
- cancer_type_detailed
- —
- subtype
- fetal
- cancer_type
- fetal
- subtype
- fetal
- sex
- fetal
- race
- fetal
- fetal_age_hindbrain
- 6
- umap1_2d
- -4.600548857
- umap2_2d
- 3.035194211
- umap1_3d
- -2.877593524
- umap2_3d
- 3.062516864
- umap3_3d
- -1.404476198
- dataset
- fetal
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2598196 | fetal | fetal | 0.971 |
| 2 | ERR2598195 | fetal | fetal | 0.945 |
| 3 | ERR2598213 | fetal | fetal | 0.944 |
| 4 | ERR2598229 | fetal | fetal | 0.934 |
| 5 | ERR2598206 | fetal | fetal | 0.930 |
| 6 | ERR2598208 | fetal | fetal | 0.929 |
| 7 | CA366342-0949-4941-8AE6-984BAF032886 | — | — | 0.920 |
| 8 | E3A67B7B-7427-4C11-912B-166451072767 | — | — | 0.917 |
| 9 | SJEPD031150_D1.RNA-Seq | EPN | EPN Tumor | 0.916 |
| 10 | 2DA298A9-AB20-4F9D-B83F-C7FC0679F889 | — | — | 0.912 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 18 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.650 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.630 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.570 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.470 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.400 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.380 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.330 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.330 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.320 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.320 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.320 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.310 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.240 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.210 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.180 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.070 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.050 | Cobimetinib | — uncovered |
| GLYCOLYSIS | 0.010 | Inavolisib | — uncovered |