ERR2598196
fetal · fetal
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- fetal
- cancer_type_detailed
- —
- subtype
- fetal
- cancer_type
- fetal
- subtype
- fetal
- sex
- fetal
- race
- fetal
- fetal_age_hindbrain
- 6
- umap1_2d
- -4.649166922
- umap2_2d
- 3.178310152
- umap1_3d
- -2.813545331
- umap2_3d
- 3.124959356
- umap3_3d
- -1.520093954
- dataset
- fetal
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.650
- E2F_TARGETS+0.640
- MYC_TARGETS_V1+0.590
- NOTCH_SIGNALING+0.530
- MITOTIC_SPINDLE+0.450
- HEDGEHOG_SIGNALING+0.440
- UNFOLDED_PROTEIN_RESPONSE+0.400
- PROTEIN_SECRETION+0.390
- MTORC1_SIGNALING+0.370
- WNT_BETA_CATENIN_SIGNALING+0.340
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.610
- INTERFERON_GAMMA_RESPONSE-0.530
- ALLOGRAFT_REJECTION-0.490
- INFLAMMATORY_RESPONSE-0.480
- IL6_JAK_STAT3_SIGNALING-0.460
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.410
- MYOGENESIS-0.400
- COMPLEMENT-0.360
- TNFA_SIGNALING_VIA_NFKB-0.360
- COAGULATION-0.310
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2598198 | fetal | fetal | 0.971 |
| 2 | ERR2598208 | fetal | fetal | 0.951 |
| 3 | ERR2598229 | fetal | fetal | 0.940 |
| 4 | ERR2598195 | fetal | fetal | 0.931 |
| 5 | E3A67B7B-7427-4C11-912B-166451072767 | — | — | 0.926 |
| 6 | ERR2598213 | fetal | fetal | 0.914 |
| 7 | E528D9EE-41C3-4D4C-B16F-ABBDD6E31B84 | — | — | 0.910 |
| 8 | 2DA298A9-AB20-4F9D-B83F-C7FC0679F889 | — | — | 0.903 |
| 9 | ERR2598206 | fetal | fetal | 0.900 |
| 10 | 6E8A9288-C2F1-4DDE-B52B-7656DB802FB4 | — | — | 0.899 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 23 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.650 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.640 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.590 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.530 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.450 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.440 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.400 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.390 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.370 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.340 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.310 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.300 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.280 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.260 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.260 | Cobimetinib | — uncovered |
| TGF_BETA_SIGNALING | 0.240 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.180 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.140 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.110 | Temsirolimus | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.100 | Remibrutinib | — uncovered |