MBCProject_3947_T1_RNA
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- UV_RESPONSE_DN+0.330
- PROTEIN_SECRETION+0.190
- HEDGEHOG_SIGNALING+0.160
- KRAS_SIGNALING_UP+0.130
- NOTCH_SIGNALING+0.130
- FATTY_ACID_METABOLISM+0.080
- WNT_BETA_CATENIN_SIGNALING+0.060
- PANCREAS_BETA_CELLS+0.050
- ANDROGEN_RESPONSE-0.010
- SPERMATOGENESIS-0.030
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.500
- G2M_CHECKPOINT-0.490
- E2F_TARGETS-0.460
- MTORC1_SIGNALING-0.430
- MYC_TARGETS_V2-0.420
- INTERFERON_GAMMA_RESPONSE-0.410
- UV_RESPONSE_UP-0.390
- ESTROGEN_RESPONSE_LATE-0.380
- INFLAMMATORY_RESPONSE-0.350
- GLYCOLYSIS-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR6013544 | — | cohortA1 | 0.863 |
| 2 | SRR23303736 | — | — | 0.860 |
| 3 | MBCProject_0719_T3_RNA | — | A | 0.855 |
| 4 | ULC0424T_S49 | — | cohortA1 | 0.854 |
| 5 | SRR25617864 | — | A | 0.854 |
| 6 | BSR_17_0022_E1_S60 | — | A | 0.852 |
| 7 | BSR_10_0261_B3_S85 | — | A | 0.851 |
| 8 | dab9a230-f4f6-4692-863a-5fdcf516be24 | — | — | 0.846 |
| 9 | TCGA-A7-A0DB-01C-02R-A277-07 | — | D | 0.844 |
| 10 | SRR8613752 | — | A | 0.843 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UV_RESPONSE_DN | 0.330 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.190 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.160 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.130 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.130 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.080 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.060 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.050 | Cobimetinib | — uncovered |