SRR23303736
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- TGF_BETA_SIGNALING+0.210
- WNT_BETA_CATENIN_SIGNALING+0.140
- NOTCH_SIGNALING+0.030
- KRAS_SIGNALING_DN+0.020
- BILE_ACID_METABOLISM+0.010
- HEDGEHOG_SIGNALING+0.010
- UV_RESPONSE_DN+0.010
- PANCREAS_BETA_CELLS+0.000
- SPERMATOGENESIS-0.010
- HEME_METABOLISM-0.020
Top 10 suppressed
- MYC_TARGETS_V2-0.550
- E2F_TARGETS-0.540
- G2M_CHECKPOINT-0.510
- MTORC1_SIGNALING-0.480
- OXIDATIVE_PHOSPHORYLATION-0.440
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.420
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- MYC_TARGETS_V1-0.390
- UNFOLDED_PROTEIN_RESPONSE-0.390
- CHOLESTEROL_HOMEOSTASIS-0.370
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | C3N-03420 | — | cohortA1 | 0.929 |
| 2 | SRR1516050 | — | — | 0.929 |
| 3 | dab9a230-f4f6-4692-863a-5fdcf516be24 | — | — | 0.923 |
| 4 | SRR8942980 | — | — | 0.914 |
| 5 | SRR1516063 | — | — | 0.905 |
| 6 | SRR1516060 | — | — | 0.902 |
| 7 | TCGA-XF-A8HI-01A-11R-A38B-07 | — | — | 0.898 |
| 8 | TCGA-A7-A13G-01B-04R-A22O-07 | — | D | 0.897 |
| 9 | SRR6013517 | — | cohortA1 | 0.893 |
| 10 | SRR11296800 | — | — | 0.892 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| TGF_BETA_SIGNALING | 0.210 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.140 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.030 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.020 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.010 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.010 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.010 | Inavolisib | — uncovered |