SRR25617864
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.340
- UV_RESPONSE_DN+0.150
- PANCREAS_BETA_CELLS+0.140
- WNT_BETA_CATENIN_SIGNALING+0.140
- NOTCH_SIGNALING+0.130
- MYOGENESIS+0.090
- ANGIOGENESIS+0.080
- PROTEIN_SECRETION+0.080
- TGF_BETA_SIGNALING+0.060
- HEME_METABOLISM+0.050
Top 10 suppressed
- E2F_TARGETS-0.570
- G2M_CHECKPOINT-0.500
- MYC_TARGETS_V1-0.500
- ESTROGEN_RESPONSE_LATE-0.400
- MTORC1_SIGNALING-0.400
- ESTROGEN_RESPONSE_EARLY-0.370
- INTERFERON_ALPHA_RESPONSE-0.360
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.320
- UNFOLDED_PROTEIN_RESPONSE-0.300
- TNFA_SIGNALING_VIA_NFKB-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-C8-A3M7-01A-12R-A21T-07 | — | A | 0.871 |
| 2 | MBCProject_3947_T1_RNA | — | A | 0.854 |
| 3 | SRR1313172 | — | A | 0.852 |
| 4 | SRR8943020 | — | — | 0.851 |
| 5 | C3N-02145 | — | cohortA1 | 0.849 |
| 6 | TCGA-A2-A4RW-01A-21R-A266-07 | — | A | 0.837 |
| 7 | SRR8613705 | — | A | 0.835 |
| 8 | SRR25617871 | — | C | 0.832 |
| 9 | TCGA-CQ-7072-01A-21R-A30B-07 | — | — | 0.828 |
| 10 | TCGA-E2-A15D-01A-11R-A115-07 | — | A | 0.825 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.340 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.150 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.140 | Cobimetinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.140 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.130 | Inavolisib | — uncovered |
| MYOGENESIS | 0.090 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.080 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.080 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.060 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.050 | Temsirolimus | — uncovered |