ec882950-7595-4ab7-a8b8-86d1422a948a
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.400
- G2M_CHECKPOINT+0.400
- MYC_TARGETS_V2+0.400
- MITOTIC_SPINDLE+0.300
- MYC_TARGETS_V1+0.300
- NOTCH_SIGNALING+0.200
- SPERMATOGENESIS+0.200
- WNT_BETA_CATENIN_SIGNALING+0.200
- ANDROGEN_RESPONSE+0.100
- HEDGEHOG_SIGNALING+0.100
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.500
- ALLOGRAFT_REJECTION-0.400
- APOPTOSIS-0.400
- CHOLESTEROL_HOMEOSTASIS-0.400
- COAGULATION-0.400
- COMPLEMENT-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- OXIDATIVE_PHOSPHORYLATION-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_KABQQA0T | Diffuse intrinsic pontine glioma | — | 0.886 |
| 2 | SRR8613800 | — | D | 0.886 |
| 3 | BS_44A3ES23 | medulloblastoma | — | 0.885 |
| 4 | SRR10899974 | — | — | 0.883 |
| 5 | 7478db87-0751-4771-941f-9fccdf01853d | — | — | 0.878 |
| 6 | TCGA-56-8083-01A-11R-2247-07 | — | cohortMD1 | 0.876 |
| 7 | ERR2208946 | — | — | 0.875 |
| 8 | SAMN03290896 | — | — | 0.873 |
| 9 | SAMN03290918 | — | — | 0.872 |
| 10 | SRR5088819 | — | — | 0.862 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.400 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.400 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.400 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.300 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.300 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.200 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.200 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.200 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.100 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.100 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.100 | Inavolisib | — uncovered |