Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · brain-umap@2

SRR665670

GTEX

60bde7a0-19cf-567f-af28-9d292bfb3032

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
—
subtype
—
cancer_type
GTEX
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.402
  • ALLOGRAFT_REJECTION+0.320
  • INTERFERON_GAMMA_RESPONSE+0.299
  • IL6_JAK_STAT3_SIGNALING+0.285
  • INFLAMMATORY_RESPONSE+0.244
  • MYOGENESIS+0.209
  • BILE_ACID_METABOLISM+0.208
  • COMPLEMENT+0.167
  • COAGULATION+0.150
  • KRAS_SIGNALING_UP+0.144

Top 10 suppressed

  • MYC_TARGETS_V2-0.415
  • G2M_CHECKPOINT-0.382
  • UNFOLDED_PROTEIN_RESPONSE-0.336
  • E2F_TARGETS-0.332
  • MYC_TARGETS_V1-0.292
  • MTORC1_SIGNALING-0.285
  • DNA_REPAIR-0.270
  • HEDGEHOG_SIGNALING-0.222
  • NOTCH_SIGNALING-0.219
  • GLYCOLYSIS-0.209

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1375952
brain-umap@2
GTEX—0.873
2SRR1414684
brain-umap@2
GTEX—0.861
3TCGA-44-2661-01A-01R-1107-07
lung-landscapes@6
—cohortA10.856
4TCGA-97-A4M6-01A-11R-A24X-07
lung-landscapes@6
—cohortA10.854
5TCGA-OR-A5LN-01
acc-tcga-pancan-2018@2018
Adrenocortical CarcinomaAdrenocortical Carcinoma, Usual Type0.849
6X1c87996e.59e7.495f.8c4e.f578c7e10ba8
lung-landscapes@6
—cohortMD20.839
739927c92-75d7-424c-9bcd-63def0075a1d
melanoma-umap@29
——0.835
8TCGA-QK-A652-01A-11R-A30B-07
head-neck@1
——0.833
9TCGA-97-A4LX-01A-11R-A24X-07
lung-landscapes@6
—cohortA10.832
10TCGA-86-8671-01A-11R-2403-07
lung-landscapes@6
—cohortMD20.827

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.402Inavolisib— uncovered
ALLOGRAFT_REJECTION0.320Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.299Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.285Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.244Idelalisib— uncovered
MYOGENESIS0.209Inavolisib— uncovered
BILE_ACID_METABOLISM0.208Inavolisib— uncovered
COMPLEMENT0.167Inavolisib— uncovered
COAGULATION0.150Binimetinib— uncovered
KRAS_SIGNALING_UP0.144Inavolisib— uncovered
APOPTOSIS0.111Idelalisib— uncovered
APICAL_SURFACE0.099Temsirolimus— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.074Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.067Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.067Inavolisib— uncovered
IL2_STAT5_SIGNALING0.061Idelalisib— uncovered
ADIPOGENESIS0.057Inavolisib— uncovered
FATTY_ACID_METABOLISM0.023Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.017Inavolisib— uncovered