SRR1313115
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ESTROGEN_RESPONSE_LATE+0.100
- ESTROGEN_RESPONSE_EARLY+0.080
- MYOGENESIS+0.050
- WNT_BETA_CATENIN_SIGNALING+0.050
- KRAS_SIGNALING_DN+0.020
- DNA_REPAIR-0.020
- SPERMATOGENESIS-0.020
- P53_PATHWAY-0.030
- ANGIOGENESIS-0.060
- TNFA_SIGNALING_VIA_NFKB-0.070
Top 10 suppressed
- MYC_TARGETS_V1-0.480
- PROTEIN_SECRETION-0.460
- ANDROGEN_RESPONSE-0.430
- MTORC1_SIGNALING-0.400
- ADIPOGENESIS-0.390
- CHOLESTEROL_HOMEOSTASIS-0.390
- OXIDATIVE_PHOSPHORYLATION-0.350
- IL6_JAK_STAT3_SIGNALING-0.340
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.340
- UNFOLDED_PROTEIN_RESPONSE-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1313093 | — | B | 0.928 |
| 2 | R87 | — | — | 0.872 |
| 3 | SRR4195662 | — | — | 0.868 |
| 4 | TCGA-CU-A3YL-01A-11R-A22U-07 | — | — | 0.866 |
| 5 | 20040121.LumB | — | D | 0.866 |
| 6 | SRR23303775 | — | — | 0.861 |
| 7 | SRR650134 | — | — | 0.858 |
| 8 | ERR4976607 | — | B | 0.857 |
| 9 | ea635e80-1225-4f52-a6cf-8f4c20201240 | — | — | 0.854 |
| 10 | SRR1478032 | GTEX | — | 0.853 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ESTROGEN_RESPONSE_LATE | 0.100 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.080 | Inavolisib | — uncovered |
| MYOGENESIS | 0.050 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.050 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.020 | Remibrutinib | — uncovered |