Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0
Sign in

SRR1384234

GTEX

7093c35b-c7c3-5457-a877-4271770583c6

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.204
  • DNA_REPAIR+0.051
  • MITOTIC_SPINDLE-0.004
  • MYOGENESIS-0.009
  • PI3K_AKT_MTOR_SIGNALING-0.015
  • SPERMATOGENESIS-0.028
  • MYC_TARGETS_V1-0.074
  • PEROXISOME-0.089
  • PANCREAS_BETA_CELLS-0.092
  • APICAL_JUNCTION-0.094

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.617
  • TNFA_SIGNALING_VIA_NFKB-0.538
  • INTERFERON_GAMMA_RESPONSE-0.513
  • INFLAMMATORY_RESPONSE-0.502
  • IL6_JAK_STAT3_SIGNALING-0.500
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.492
  • APOPTOSIS-0.448
  • TGF_BETA_SIGNALING-0.435
  • KRAS_SIGNALING_UP-0.425
  • IL2_STAT5_SIGNALING-0.424

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1324452
brain-umap@2
GTEX0.986
2SRR1441200
brain-umap@2
GTEX0.983
3SRR1331841
brain-umap@2
GTEX0.983
4SRR1459033
brain-umap@2
GTEX0.982
5SRR1439850
brain-umap@2
GTEX0.982
6SRR1317808
brain-umap@2
GTEX0.981
7SRR1338323
brain-umap@2
GTEX0.980
8SRR1328960
brain-umap@2
GTEX0.980
9SRR1467255
brain-umap@2
GTEX0.980
10SRR1341605
brain-umap@2
GTEX0.980

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 2 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.204Remibrutinib— uncovered
DNA_REPAIR0.051Idelalisib— uncovered