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SRR1439850

GTEX

94193084-0f56-57ab-b411-a39a68fda221

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.184
  • SPERMATOGENESIS+0.045
  • DNA_REPAIR+0.028
  • MITOTIC_SPINDLE+0.004
  • MYC_TARGETS_V2-0.037
  • PI3K_AKT_MTOR_SIGNALING-0.044
  • PANCREAS_BETA_CELLS-0.060
  • G2M_CHECKPOINT-0.061
  • E2F_TARGETS-0.096
  • MYOGENESIS-0.119

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.589
  • INTERFERON_GAMMA_RESPONSE-0.516
  • TNFA_SIGNALING_VIA_NFKB-0.480
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.469
  • APOPTOSIS-0.456
  • IL6_JAK_STAT3_SIGNALING-0.448
  • TGF_BETA_SIGNALING-0.433
  • INFLAMMATORY_RESPONSE-0.426
  • NOTCH_SIGNALING-0.417
  • ANGIOGENESIS-0.409

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1429935
brain-umap@2
GTEX0.991
2SRR1402513
brain-umap@2
GTEX0.987
3SRR1338323
brain-umap@2
GTEX0.986
4SRR1324452
brain-umap@2
GTEX0.985
5SRR1317808
brain-umap@2
GTEX0.984
6SRR1457418
brain-umap@2
GTEX0.984
7SRR1431366
brain-umap@2
GTEX0.984
8SRR1434271
brain-umap@2
GTEX0.982
9SRR1384234
brain-umap@2
GTEX0.982
10SRR1465132
brain-umap@2
GTEX0.980

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.184Remibrutinib— uncovered
SPERMATOGENESIS0.045Inavolisib— uncovered
DNA_REPAIR0.028Idelalisib— uncovered
MITOTIC_SPINDLE0.004Inavolisib— uncovered