SRR1797238
— · cohortSC
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortSC
- subtype
- cohortSC
- age_years
- 62
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.340
- WNT_BETA_CATENIN_SIGNALING+0.200
- DNA_REPAIR+0.170
- HEDGEHOG_SIGNALING+0.090
- SPERMATOGENESIS+0.060
- BILE_ACID_METABOLISM+0.020
- KRAS_SIGNALING_DN+0.010
- OXIDATIVE_PHOSPHORYLATION+0.010
- NOTCH_SIGNALING-0.030
- MYOGENESIS-0.050
Top 10 suppressed
- ANGIOGENESIS-0.550
- IL6_JAK_STAT3_SIGNALING-0.510
- ALLOGRAFT_REJECTION-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- TNFA_SIGNALING_VIA_NFKB-0.480
- INFLAMMATORY_RESPONSE-0.470
- KRAS_SIGNALING_UP-0.460
- INTERFERON_GAMMA_RESPONSE-0.430
- G2M_CHECKPOINT-0.420
- ANDROGEN_RESPONSE-0.410
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-0029 | Med | Medulloblastoma | 0.921 |
| 2 | SRR1797247 | — | cohortSC | 0.917 |
| 3 | SRR1516072 | — | — | 0.916 |
| 4 | MDT-AP-1160 | Med | Medulloblastoma | 0.912 |
| 5 | TCGA-37-4129-01A-01R-1100-07 | — | cohortSC | 0.909 |
| 6 | MDT-AP-1405 | Med | Medulloblastoma | 0.903 |
| 7 | MNG199 | — | — | 0.901 |
| 8 | MDT-AP-1345 | Med | Medulloblastoma | 0.900 |
| 9 | TCGA-E9-A245-01A-22R-A16F-07 | — | B | 0.899 |
| 10 | MNG851 | — | — | 0.898 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.340 | Cobimetinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.200 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.170 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.090 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.060 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.020 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.010 | Remibrutinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.010 | Remibrutinib | — uncovered |