MDT-AP-1160
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- overall_survival_months
- 80.03999999999999
- os_event
- false
- age_years
- 12.8
- sex
- M
- new_clusters
- C3
- umap1_2d
- 6.095199221
- umap2_2d
- 3.861398703
- umap1_3d
- 2.839823813
- umap2_3d
- -1.584074687
- umap3_3d
- -1.915296949
- dataset
- Med-Taylor
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.220
- KRAS_SIGNALING_DN+0.200
- WNT_BETA_CATENIN_SIGNALING+0.180
- SPERMATOGENESIS+0.150
- DNA_REPAIR+0.020
- HEDGEHOG_SIGNALING-0.040
- PEROXISOME-0.100
- HEME_METABOLISM-0.110
- P53_PATHWAY-0.110
- XENOBIOTIC_METABOLISM-0.120
Top 10 suppressed
- MYC_TARGETS_V1-0.530
- G2M_CHECKPOINT-0.510
- E2F_TARGETS-0.490
- INTERFERON_ALPHA_RESPONSE-0.480
- MTORC1_SIGNALING-0.460
- INFLAMMATORY_RESPONSE-0.440
- TNFA_SIGNALING_VIA_NFKB-0.430
- INTERFERON_GAMMA_RESPONSE-0.420
- ANDROGEN_RESPONSE-0.410
- COMPLEMENT-0.410
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1516050 | — | — | 0.943 |
| 2 | SRR1797231 | — | cohortSC | 0.939 |
| 3 | MDT-AP-0394 | Med | Medulloblastoma | 0.936 |
| 4 | SRR1334717 | GTEX | — | 0.930 |
| 5 | TCGA-E7-A3Y1-01A-11R-A22U-07 | — | — | 0.929 |
| 6 | MDT-AP-1136 | Med | Medulloblastoma | 0.922 |
| 7 | SRR1321183 | GTEX | — | 0.922 |
| 8 | SRR1797247 | — | cohortSC | 0.921 |
| 9 | SRR1478032 | GTEX | — | 0.920 |
| 10 | MDT-AP-2034 | Med | Medulloblastoma | 0.920 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.220 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.200 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.180 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.150 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.020 | Idelalisib | — uncovered |