Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

C3N-01413

· cohortA1

731a0909-f4ef-5200-a4a5-961d82aeed47

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA1
subtype
cohortA1
age_years
62.16016427

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ee0e68bf-7fa0-4edc-a9df-30a63c2db34a
melanoma-umap@29
0.877
2TCGA-L9-A444-01A-21R-A24H-07
lung-landscapes@6
cohortA10.873
3TCGA-22-1005-01A-01R-0692-07
lung-landscapes@6
cohortMD20.859
4TCGA-CF-A47V-01A-11R-A23W-07
bladder-landscape@3
0.859
5SRR12202445
bladder-landscape@3
0.858
6TCGA-55-8621-01A-11R-2403-07
lung-landscapes@6
cohortA10.856
7SRR12202486
bladder-landscape@3
0.855
8TCGA-86-8671-01A-11R-2403-07
lung-landscapes@6
cohortMD20.855
9C3N-03057
lung-landscapes@6
cohortA10.854
10TCGA-44-2657-01A-01R-1107-07
lung-landscapes@6
cohortA10.851

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.570Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.440Idelalisib— uncovered
APICAL_SURFACE0.220Temsirolimus— uncovered
ALLOGRAFT_REJECTION0.190Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.190Inavolisib— uncovered
KRAS_SIGNALING_UP0.170Inavolisib— uncovered
COAGULATION0.160Binimetinib— uncovered
HEDGEHOG_SIGNALING0.150Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.140Idelalisib— uncovered
KRAS_SIGNALING_DN0.140Remibrutinib— uncovered
BILE_ACID_METABOLISM0.110Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.090Inavolisib— uncovered
PANCREAS_BETA_CELLS0.080Cobimetinib— uncovered
COMPLEMENT0.050Inavolisib— uncovered
MYOGENESIS0.040Inavolisib— uncovered
UV_RESPONSE_DN0.040Inavolisib— uncovered
NOTCH_SIGNALING0.030Inavolisib— uncovered
IL2_STAT5_SIGNALING0.020Idelalisib— uncovered
SPERMATOGENESIS0.020Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.010Inavolisib— uncovered