SRR818348
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.478
- TNFA_SIGNALING_VIA_NFKB+0.396
- CHOLESTEROL_HOMEOSTASIS+0.352
- MTORC1_SIGNALING+0.328
- OXIDATIVE_PHOSPHORYLATION+0.305
- INFLAMMATORY_RESPONSE+0.303
- UV_RESPONSE_UP+0.301
- ANGIOGENESIS+0.297
- HYPOXIA+0.284
- INTERFERON_GAMMA_RESPONSE+0.248
Top 10 suppressed
- G2M_CHECKPOINT-0.410
- MITOTIC_SPINDLE-0.379
- E2F_TARGETS-0.375
- UV_RESPONSE_DN-0.283
- NOTCH_SIGNALING-0.181
- DNA_REPAIR-0.117
- TGF_BETA_SIGNALING-0.112
- WNT_BETA_CATENIN_SIGNALING-0.081
- PROTEIN_SECRETION-0.020
- BILE_ACID_METABOLISM-0.018
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR820518 | GTEX | — | 0.903 |
| 2 | SRR1071880 | GTEX | — | 0.894 |
| 3 | SRR1488349 | GTEX | — | 0.875 |
| 4 | SRR1466871 | GTEX | — | 0.855 |
| 5 | SRR1374414 | GTEX | — | 0.854 |
| 6 | SRR1347688 | GTEX | — | 0.844 |
| 7 | SRR1444102 | GTEX | — | 0.843 |
| 8 | SRR1445514 | GTEX | — | 0.826 |
| 9 | SRR8752372 | — | — | 0.798 |
| 10 | MNG610 | — | — | 0.795 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 39 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.478 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.396 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.352 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.328 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.305 | Remibrutinib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.303 | Idelalisib | — uncovered |
| UV_RESPONSE_UP | 0.301 | Idelalisib | — uncovered |
| ANGIOGENESIS | 0.297 | Remibrutinib | — uncovered |
| HYPOXIA | 0.284 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.248 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.237 | Cobimetinib | — uncovered |
| PEROXISOME | 0.231 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.220 | Idelalisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.213 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.205 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.201 | Idelalisib | — uncovered |
| COAGULATION | 0.198 | Binimetinib | — uncovered |
| APOPTOSIS | 0.197 | Idelalisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.180 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.179 | Inavolisib | — uncovered |