Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_5P3CZQV8

Neurofibroma

757fabb5-277a-51b7-a5e4-b19c6d269643

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Neurofibroma
cancer_type_detailed
subtype
cancer_type
Neurofibroma
overall_survival_months
32.35873850197109
age_years
12.636
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_D4PJYHZ2
brain-umap@2
Neurofibroma0.953
2SRR2689710
melanoma-umap@29
0.916
3TCGA-A2-A0CO-01A-13R-A22K-07
breast-umap@18
A0.916
4BS_FQX1PRAJ
brain-umap@2
Neurofibroma0.916
5BS_Z28VKGNS
brain-umap@2
Neurofibroma0.915
6BS_GDHH6T5A
brain-umap@2
Neurofibroma0.915
77c6f92ab-6cf8-4293-b676-2619c40f6ee6
colon-landscapes@1
0.914
8BS_69V8P8A0
brain-umap@2
Neurofibroma0.912
97f51ff28-397d-466f-82b0-25e9c9182ea7
melanoma-umap@29
0.911
10MDT-AP-1125
medullo-epn-umap@date-based
MedMedulloblastoma0.911

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.478Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.450Inavolisib— uncovered
COAGULATION0.410Binimetinib— uncovered
INTERFERON_ALPHA_RESPONSE0.396Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.393Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.387Inavolisib— uncovered
MYOGENESIS0.379Inavolisib— uncovered
APICAL_JUNCTION0.354Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.335Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.325Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.315Idelalisib— uncovered
P53_PATHWAY0.311Idelalisib— uncovered
KRAS_SIGNALING_DN0.285Remibrutinib— uncovered
CHOLESTEROL_HOMEOSTASIS0.263Remibrutinib— uncovered
NOTCH_SIGNALING0.260Inavolisib— uncovered
APOPTOSIS0.254Idelalisib— uncovered
APICAL_SURFACE0.252Temsirolimus— uncovered
IL2_STAT5_SIGNALING0.233Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.231Idelalisib— uncovered
UV_RESPONSE_DN0.221Inavolisib— uncovered