30608f63-2604-489c-bf96-09e56acfe912
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.700
- INTERFERON_GAMMA_RESPONSE+0.600
- ALLOGRAFT_REJECTION+0.400
- IL6_JAK_STAT3_SIGNALING+0.400
- COMPLEMENT+0.200
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.200
- INFLAMMATORY_RESPONSE+0.200
- COAGULATION+0.100
- IL2_STAT5_SIGNALING+0.100
- MITOTIC_SPINDLE+0.100
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.600
- MYC_TARGETS_V1-0.500
- PANCREAS_BETA_CELLS-0.500
- GLYCOLYSIS-0.400
- MTORC1_SIGNALING-0.400
- MYC_TARGETS_V2-0.400
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- UNFOLDED_PROTEIN_RESPONSE-0.400
- ADIPOGENESIS-0.300
- E2F_TARGETS-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | be8d8236-4ebc-46de-a4fd-a901fec1cdce | — | — | 0.883 |
| 2 | C3N-00433 | — | cohortMD2 | 0.874 |
| 3 | SRR1313132 | — | D | 0.873 |
| 4 | TCGA-22-1005-01A-01R-A96U-41 | — | cohortMD2 | 0.866 |
| 5 | BS_J6VKB1VE | low-grade glioma | — | 0.855 |
| 6 | SRR12696760 | — | — | 0.855 |
| 7 | SRR5088847 | — | — | 0.847 |
| 8 | TCGA-E9-A2JT-01A-22R-A18M-07 | — | D | 0.843 |
| 9 | TCGA-86-6851-01A-11R-1949-07 | — | cohortA1 | 0.839 |
| 10 | TCGA-MP-A4T4-01A-11R-A262-07 | — | cohortA1 | 0.838 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.700 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.600 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.400 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.400 | Inavolisib | — uncovered |
| COMPLEMENT | 0.200 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.200 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.200 | Idelalisib | — uncovered |
| COAGULATION | 0.100 | Binimetinib | — uncovered |
| IL2_STAT5_SIGNALING | 0.100 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.100 | Inavolisib | — uncovered |