Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-QK-A64Z-01A-11R-A30B-07

78768b99-6cae-588e-85b8-aa59a50d0b43

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.146347032
sex
female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.580
  • INTERFERON_GAMMA_RESPONSE+0.310
  • PROTEIN_SECRETION+0.270
  • DNA_REPAIR+0.230
  • OXIDATIVE_PHOSPHORYLATION+0.210
  • NOTCH_SIGNALING+0.180
  • UNFOLDED_PROTEIN_RESPONSE+0.180
  • APICAL_SURFACE+0.130
  • MYC_TARGETS_V2+0.130
  • P53_PATHWAY+0.090

Top 10 suppressed

  • MYOGENESIS-0.370
  • IL2_STAT5_SIGNALING-0.350
  • E2F_TARGETS-0.340
  • MITOTIC_SPINDLE-0.300
  • KRAS_SIGNALING_UP-0.280
  • G2M_CHECKPOINT-0.270
  • ALLOGRAFT_REJECTION-0.250
  • HYPOXIA-0.250
  • XENOBIOTIC_METABOLISM-0.240
  • ESTROGEN_RESPONSE_EARLY-0.230

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR12202456
bladder-landscape@3
0.724
2SRR1516087
bladder-landscape@3
0.702
3SRR23303762
bladder-landscape@3
0.698
4TCGA-T2-A6X2-01A-12R-A34R-07
head-neck@1
0.670
5X7c156f05.aaca.4c79.bdb2.94044d5422e8
lung-landscapes@6
cohortA10.667
6TCGA-ZF-A9R5-01A-12R-A42T-07
bladder-landscape@3
0.662
7SRR6013584
lung-landscapes@6
cohortA10.654
8R10
bladder-landscape@3
0.643
90a4a9b5b-90d9-4789-af04-f931433808c1
colon-landscapes@1
0.634
10SRR8942997
bladder-landscape@3
0.634

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 17 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.580Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.310Idelalisib— uncovered
PROTEIN_SECRETION0.270Remibrutinib— uncovered
DNA_REPAIR0.230Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.210Remibrutinib— uncovered
NOTCH_SIGNALING0.180Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.180Idelalisib— uncovered
APICAL_SURFACE0.130Temsirolimus— uncovered
MYC_TARGETS_V20.130Idelalisib— uncovered
P53_PATHWAY0.090Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.090Inavolisib— uncovered
ANGIOGENESIS0.070Remibrutinib— uncovered
UV_RESPONSE_UP0.070Idelalisib— uncovered
MYC_TARGETS_V10.050Inavolisib— uncovered
COAGULATION0.030Binimetinib— uncovered
ADIPOGENESIS0.020Inavolisib— uncovered
PANCREAS_BETA_CELLS0.010Cobimetinib— uncovered