SRR8942987
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.330
- KRAS_SIGNALING_DN+0.260
- INTERFERON_ALPHA_RESPONSE+0.120
- INTERFERON_GAMMA_RESPONSE+0.050
- ALLOGRAFT_REJECTION+0.000
- SPERMATOGENESIS+0.000
- APICAL_SURFACE-0.030
- IL6_JAK_STAT3_SIGNALING-0.040
- XENOBIOTIC_METABOLISM-0.060
- HEDGEHOG_SIGNALING-0.070
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.520
- ADIPOGENESIS-0.420
- PROTEIN_SECRETION-0.400
- MYC_TARGETS_V1-0.380
- IL2_STAT5_SIGNALING-0.370
- APOPTOSIS-0.350
- ANGIOGENESIS-0.340
- MTORC1_SIGNALING-0.340
- UV_RESPONSE_DN-0.340
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-1327 | Med | Medulloblastoma | 0.920 |
| 2 | TCGA-49-AARQ-01A-11R-A41B-07 | — | cohortA1 | 0.919 |
| 3 | SRR8942981 | — | — | 0.906 |
| 4 | SRR13311179 | — | — | 0.905 |
| 5 | SRR11296796 | — | — | 0.899 |
| 6 | SRR13311161 | — | — | 0.895 |
| 7 | SRR1366141 | GTEX | — | 0.893 |
| 8 | SRR13311156 | — | — | 0.892 |
| 9 | MNG599 | — | — | 0.891 |
| 10 | SRR4195690 | — | — | 0.889 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.330 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.260 | Remibrutinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.120 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.050 | Idelalisib | — uncovered |