SRR4195690
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.390
- KRAS_SIGNALING_DN+0.270
- INTERFERON_ALPHA_RESPONSE+0.210
- APICAL_SURFACE+0.160
- PANCREAS_BETA_CELLS+0.130
- INTERFERON_GAMMA_RESPONSE+0.110
- MYOGENESIS+0.020
- ALLOGRAFT_REJECTION-0.020
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.070
- APICAL_JUNCTION-0.090
Top 10 suppressed
- TGF_BETA_SIGNALING-0.530
- PROTEIN_SECRETION-0.500
- ANDROGEN_RESPONSE-0.480
- UNFOLDED_PROTEIN_RESPONSE-0.440
- FATTY_ACID_METABOLISM-0.430
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.410
- UV_RESPONSE_DN-0.410
- ADIPOGENESIS-0.400
- OXIDATIVE_PHOSPHORYLATION-0.400
- XENOBIOTIC_METABOLISM-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR8942981 | — | — | 0.904 |
| 2 | SRR4195666 | — | — | 0.891 |
| 3 | SRR8942987 | — | — | 0.889 |
| 4 | MNG599 | — | — | 0.887 |
| 5 | SRR4195695 | — | — | 0.885 |
| 6 | AUR-AD9G-TTP1-B-4-0-R-A584-39 | — | D | 0.884 |
| 7 | TCGA-49-AARQ-01A-11R-A41B-07 | — | cohortA1 | 0.884 |
| 8 | SRR11296796 | — | — | 0.875 |
| 9 | MDT-AP-1327 | Med | Medulloblastoma | 0.875 |
| 10 | SRR598533 | GTEX | — | 0.873 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.390 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.270 | Remibrutinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.210 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.160 | Temsirolimus | — uncovered |
| PANCREAS_BETA_CELLS | 0.130 | Cobimetinib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.110 | Idelalisib | — uncovered |
| MYOGENESIS | 0.020 | Inavolisib | — uncovered |