SRR1366141
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.482
- PANCREAS_BETA_CELLS+0.337
- SPERMATOGENESIS+0.248
- MYOGENESIS+0.054
- COAGULATION-0.010
- HEDGEHOG_SIGNALING-0.022
- ESTROGEN_RESPONSE_LATE-0.028
- ALLOGRAFT_REJECTION-0.049
- APICAL_SURFACE-0.053
- KRAS_SIGNALING_UP-0.095
Top 10 suppressed
- MYC_TARGETS_V1-0.594
- PROTEIN_SECRETION-0.577
- MTORC1_SIGNALING-0.566
- OXIDATIVE_PHOSPHORYLATION-0.536
- UNFOLDED_PROTEIN_RESPONSE-0.512
- ANDROGEN_RESPONSE-0.505
- DNA_REPAIR-0.495
- MYC_TARGETS_V2-0.475
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.434
- ADIPOGENESIS-0.431
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG597 | — | — | 0.980 |
| 2 | 08e3d239-3d8a-4eee-9e08-ac2bcb3f2619 | — | — | 0.978 |
| 3 | MNG1259 | — | — | 0.974 |
| 4 | SRR1385080 | GTEX | — | 0.974 |
| 5 | MNG598 | — | — | 0.973 |
| 6 | msclc569389_S35.txt | — | cohortMD1 | 0.971 |
| 7 | TCGA-CF-A3MF-01A-12R-A21D-07 | — | — | 0.971 |
| 8 | MNG1246 | — | — | 0.970 |
| 9 | MNG555 | — | — | 0.970 |
| 10 | SRR1323130 | GTEX | — | 0.969 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.482 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.337 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.248 | Inavolisib | — uncovered |
| MYOGENESIS | 0.054 | Inavolisib | — uncovered |