SRR661325
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.365
- OXIDATIVE_PHOSPHORYLATION+0.345
- PROTEIN_SECRETION+0.312
- UV_RESPONSE_DN+0.171
- KRAS_SIGNALING_DN+0.143
- ANDROGEN_RESPONSE+0.128
- MYC_TARGETS_V1+0.118
- PANCREAS_BETA_CELLS+0.071
- PEROXISOME+0.037
- FATTY_ACID_METABOLISM+0.020
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.496
- CHOLESTEROL_HOMEOSTASIS-0.437
- NOTCH_SIGNALING-0.429
- IL6_JAK_STAT3_SIGNALING-0.421
- WNT_BETA_CATENIN_SIGNALING-0.384
- INTERFERON_GAMMA_RESPONSE-0.383
- TNFA_SIGNALING_VIA_NFKB-0.377
- P53_PATHWAY-0.354
- INFLAMMATORY_RESPONSE-0.321
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.317
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR657754 | GTEX | — | 0.920 |
| 2 | SRR659235 | GTEX | — | 0.918 |
| 3 | SRR820623 | GTEX | — | 0.900 |
| 4 | SRR655649 | GTEX | — | 0.900 |
| 5 | SRR2167030 | GTEX | — | 0.890 |
| 6 | SRR658129 | GTEX | — | 0.889 |
| 7 | SRR818210 | GTEX | — | 0.880 |
| 8 | SRR663753 | GTEX | — | 0.874 |
| 9 | SRR821626 | GTEX | — | 0.873 |
| 10 | SRR1471943 | GTEX | — | 0.868 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.365 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.345 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.312 | Remibrutinib | — uncovered |
| UV_RESPONSE_DN | 0.171 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.143 | Remibrutinib | — uncovered |
| ANDROGEN_RESPONSE | 0.128 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.118 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.071 | Cobimetinib | — uncovered |
| PEROXISOME | 0.037 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.020 | Inavolisib | — uncovered |