SRR1390601
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.352
- SPERMATOGENESIS+0.341
- HEDGEHOG_SIGNALING+0.270
- KRAS_SIGNALING_DN+0.270
- MYOGENESIS+0.159
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.110
- UV_RESPONSE_DN+0.091
- APICAL_SURFACE+0.060
- PANCREAS_BETA_CELLS+0.046
- PI3K_AKT_MTOR_SIGNALING+0.009
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.689
- IL6_JAK_STAT3_SIGNALING-0.627
- INTERFERON_GAMMA_RESPONSE-0.609
- ALLOGRAFT_REJECTION-0.543
- INFLAMMATORY_RESPONSE-0.518
- TNFA_SIGNALING_VIA_NFKB-0.465
- E2F_TARGETS-0.416
- IL2_STAT5_SIGNALING-0.415
- COMPLEMENT-0.392
- ANGIOGENESIS-0.386
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1459718 | GTEX | — | 0.982 |
| 2 | SRR1317344 | GTEX | — | 0.979 |
| 3 | SRR602728 | GTEX | — | 0.978 |
| 4 | SRR1084842 | GTEX | — | 0.974 |
| 5 | SRR821549 | GTEX | — | 0.970 |
| 6 | SRR1389979 | GTEX | — | 0.970 |
| 7 | SRR1354446 | GTEX | — | 0.968 |
| 8 | SRR1464373 | GTEX | — | 0.965 |
| 9 | SRR602704 | GTEX | — | 0.962 |
| 10 | SRR821626 | GTEX | — | 0.962 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.352 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.341 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.270 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.270 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.159 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.110 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.091 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.060 | Temsirolimus | — uncovered |
| PANCREAS_BETA_CELLS | 0.046 | Cobimetinib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.009 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.002 | Inavolisib | — uncovered |