Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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SRR1319672

GTEX

4526487f-d451-5f66-963c-b7c169149807

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • DNA_REPAIR+0.188
  • KRAS_SIGNALING_DN+0.074
  • UNFOLDED_PROTEIN_RESPONSE+0.017
  • MITOTIC_SPINDLE+0.013
  • PROTEIN_SECRETION+0.004
  • MYC_TARGETS_V2+0.001
  • PI3K_AKT_MTOR_SIGNALING-0.007
  • HEME_METABOLISM-0.026
  • MYOGENESIS-0.036
  • MYC_TARGETS_V1-0.039

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.623
  • INFLAMMATORY_RESPONSE-0.535
  • IL6_JAK_STAT3_SIGNALING-0.502
  • INTERFERON_GAMMA_RESPONSE-0.501
  • TNFA_SIGNALING_VIA_NFKB-0.498
  • ANGIOGENESIS-0.490
  • ALLOGRAFT_REJECTION-0.481
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.470
  • KRAS_SIGNALING_UP-0.437
  • APOPTOSIS-0.421

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1359367
brain-umap@2
GTEX0.988
2SRR1441224
brain-umap@2
GTEX0.987
3SRR1394450
brain-umap@2
GTEX0.987
4SRR1401552
brain-umap@2
GTEX0.986
5SRR1464305
brain-umap@2
GTEX0.985
6SRR1352415
brain-umap@2
GTEX0.984
7SRR1477385
brain-umap@2
GTEX0.984
8SRR1490568
brain-umap@2
GTEX0.983
9SRR820468
brain-umap@2
GTEX0.983
10SRR1361736
brain-umap@2
GTEX0.983

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 6 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
DNA_REPAIR0.188Idelalisib— uncovered
KRAS_SIGNALING_DN0.074Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.017Idelalisib— uncovered
MITOTIC_SPINDLE0.013Inavolisib— uncovered
PROTEIN_SECRETION0.004Remibrutinib— uncovered
MYC_TARGETS_V20.001Idelalisib— uncovered