Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG758

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873a9562-42b8-54b0-bc13-6cd4b6461e93

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.370
  • INTERFERON_GAMMA_RESPONSE+0.322
  • ALLOGRAFT_REJECTION+0.288
  • MYC_TARGETS_V1+0.287
  • ANDROGEN_RESPONSE+0.282
  • UV_RESPONSE_DN+0.257
  • PEROXISOME+0.222
  • PROTEIN_SECRETION+0.165
  • INFLAMMATORY_RESPONSE+0.136
  • KRAS_SIGNALING_UP+0.117

Top 10 suppressed

  • ANGIOGENESIS-0.417
  • G2M_CHECKPOINT-0.342
  • TNFA_SIGNALING_VIA_NFKB-0.326
  • GLYCOLYSIS-0.279
  • ESTROGEN_RESPONSE_LATE-0.275
  • ESTROGEN_RESPONSE_EARLY-0.258
  • NOTCH_SIGNALING-0.242
  • CHOLESTEROL_HOMEOSTASIS-0.234
  • MITOTIC_SPINDLE-0.228
  • E2F_TARGETS-0.222

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG73
mng-umap@100
——0.758
2MNG633
mng-umap@100
——0.740
3MNG884
mng-umap@100
——0.723
4MNG628
mng-umap@100
——0.719
5MNG881
mng-umap@100
——0.706
6MNG433
mng-umap@100
——0.699
7MNG815
mng-umap@100
——0.699
8R324
bladder-landscape@3
——0.696
9C3L-00923
lung-landscapes@6
—cohortSQ10.694
10MNG396
mng-umap@100
——0.688

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.370Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.322Idelalisib— uncovered
ALLOGRAFT_REJECTION0.288Idelalisib— uncovered
MYC_TARGETS_V10.287Inavolisib— uncovered
ANDROGEN_RESPONSE0.282Inavolisib— uncovered
UV_RESPONSE_DN0.257Inavolisib— uncovered
PEROXISOME0.222Idelalisib— uncovered
PROTEIN_SECRETION0.165Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.136Idelalisib— uncovered
KRAS_SIGNALING_UP0.117Inavolisib— uncovered
BILE_ACID_METABOLISM0.096Inavolisib— uncovered
DNA_REPAIR0.089Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.061Remibrutinib— uncovered
HEME_METABOLISM0.057Temsirolimus— uncovered
KRAS_SIGNALING_DN0.030Remibrutinib— uncovered
COMPLEMENT0.016Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.014Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.001Inavolisib— uncovered