Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG396

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116e876e-8035-541a-9a71-a5b74a73f8a1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.359
  • INTERFERON_GAMMA_RESPONSE+0.312
  • OXIDATIVE_PHOSPHORYLATION+0.304
  • PEROXISOME+0.277
  • PROTEIN_SECRETION+0.243
  • FATTY_ACID_METABOLISM+0.215
  • UV_RESPONSE_DN+0.208
  • IL6_JAK_STAT3_SIGNALING+0.173
  • TGF_BETA_SIGNALING+0.156
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.148

Top 10 suppressed

  • TNFA_SIGNALING_VIA_NFKB-0.388
  • APICAL_SURFACE-0.322
  • ANGIOGENESIS-0.283
  • COAGULATION-0.226
  • CHOLESTEROL_HOMEOSTASIS-0.225
  • ESTROGEN_RESPONSE_EARLY-0.221
  • HYPOXIA-0.212
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.209
  • UV_RESPONSE_UP-0.185
  • APOPTOSIS-0.182

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG633
mng-umap@100
——0.779
2MNG805
mng-umap@100
——0.734
3MNG430
mng-umap@100
——0.721
4MNG876
mng-umap@100
——0.713
5MNG398
mng-umap@100
——0.704
6MNG631
mng-umap@100
——0.701
7MNG884
mng-umap@100
——0.697
8MNG551
mng-umap@100
——0.695
9MNG758
mng-umap@100
——0.688
10MNG442
mng-umap@100
——0.679

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.359Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.312Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.304Remibrutinib— uncovered
PEROXISOME0.277Idelalisib— uncovered
PROTEIN_SECRETION0.243Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.215Inavolisib— uncovered
UV_RESPONSE_DN0.208Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.173Inavolisib— uncovered
TGF_BETA_SIGNALING0.156Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.148Inavolisib— uncovered
MYC_TARGETS_V10.121Inavolisib— uncovered
ALLOGRAFT_REJECTION0.110Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.094Inavolisib— uncovered
MITOTIC_SPINDLE0.085Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.080Inavolisib— uncovered
COMPLEMENT0.071Inavolisib— uncovered
ADIPOGENESIS0.069Inavolisib— uncovered
BILE_ACID_METABOLISM0.055Inavolisib— uncovered
HEDGEHOG_SIGNALING0.053Inavolisib— uncovered
MYOGENESIS0.049Inavolisib— uncovered