C3N-01842
— · cohortA3
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA3
- subtype
- cohortA3
- age_years
- 69.88911704
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.300
- PROTEIN_SECRETION+0.270
- UV_RESPONSE_DN+0.250
- G2M_CHECKPOINT+0.220
- ANGIOGENESIS+0.200
- ANDROGEN_RESPONSE+0.190
- E2F_TARGETS+0.190
- TGF_BETA_SIGNALING+0.080
- KRAS_SIGNALING_UP+0.070
- MYC_TARGETS_V1+0.070
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.490
- INTERFERON_GAMMA_RESPONSE-0.430
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- ALLOGRAFT_REJECTION-0.370
- NOTCH_SIGNALING-0.340
- P53_PATHWAY-0.340
- ADIPOGENESIS-0.320
- MYC_TARGETS_V2-0.300
- APICAL_SURFACE-0.290
- APICAL_JUNCTION-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | b503bcc9-714d-40aa-8709-3b4577ce8007 | — | — | 0.796 |
| 2 | AUR-AFSP-TTM1-A-8-0-R-A741-41 | — | D | 0.770 |
| 3 | s0122214 | — | — | 0.757 |
| 4 | C3N-01016 | — | cohortA3 | 0.754 |
| 5 | MBCProject_2346_T1_RNA | — | B | 0.745 |
| 6 | R259 | — | — | 0.738 |
| 7 | SRR2932838 | — | — | 0.734 |
| 8 | ERR2208889 | — | — | 0.729 |
| 9 | MNG640 | — | — | 0.729 |
| 10 | SRR12475135 | — | — | 0.728 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 16 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.300 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.270 | Remibrutinib | — uncovered |
| UV_RESPONSE_DN | 0.250 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.220 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.200 | Remibrutinib | — uncovered |
| ANDROGEN_RESPONSE | 0.190 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.190 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.080 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.070 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.070 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.060 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.050 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.040 | Inavolisib | — uncovered |
| HYPOXIA | 0.040 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.030 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.010 | Inavolisib | — uncovered |