SRR655684
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.251
- DNA_REPAIR+0.206
- MITOTIC_SPINDLE+0.172
- UNFOLDED_PROTEIN_RESPONSE+0.151
- MYC_TARGETS_V1+0.145
- PI3K_AKT_MTOR_SIGNALING+0.105
- OXIDATIVE_PHOSPHORYLATION+0.084
- HEME_METABOLISM+0.076
- UV_RESPONSE_UP+0.023
- PEROXISOME+0.020
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.573
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.511
- COAGULATION-0.456
- ANGIOGENESIS-0.432
- INTERFERON_GAMMA_RESPONSE-0.428
- NOTCH_SIGNALING-0.426
- INFLAMMATORY_RESPONSE-0.415
- TGF_BETA_SIGNALING-0.402
- TNFA_SIGNALING_VIA_NFKB-0.399
- KRAS_SIGNALING_UP-0.365
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR657915 | GTEX | — | 0.982 |
| 2 | SRR1410934 | GTEX | — | 0.962 |
| 3 | SRR1343115 | GTEX | — | 0.959 |
| 4 | SRR663453 | GTEX | — | 0.957 |
| 5 | SRR599225 | GTEX | — | 0.956 |
| 6 | SRR1406917 | GTEX | — | 0.955 |
| 7 | SRR1097392 | GTEX | — | 0.953 |
| 8 | SRR1397266 | GTEX | — | 0.952 |
| 9 | SRR1477773 | GTEX | — | 0.950 |
| 10 | SRR1403915 | GTEX | — | 0.949 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.251 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.206 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.172 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.151 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.145 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.105 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.084 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.076 | Temsirolimus | — uncovered |
| UV_RESPONSE_UP | 0.023 | Idelalisib | — uncovered |
| PEROXISOME | 0.020 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.018 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.017 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.012 | Inavolisib | — uncovered |