MNG537
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ALLOGRAFT_REJECTION+0.381
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.309
- IL6_JAK_STAT3_SIGNALING+0.275
- INTERFERON_GAMMA_RESPONSE+0.222
- PANCREAS_BETA_CELLS+0.196
- INTERFERON_ALPHA_RESPONSE+0.192
- MYOGENESIS+0.170
- INFLAMMATORY_RESPONSE+0.147
- KRAS_SIGNALING_DN+0.140
- WNT_BETA_CATENIN_SIGNALING+0.088
Top 10 suppressed
- CHOLESTEROL_HOMEOSTASIS-0.407
- MTORC1_SIGNALING-0.403
- PROTEIN_SECRETION-0.358
- G2M_CHECKPOINT-0.337
- E2F_TARGETS-0.317
- OXIDATIVE_PHOSPHORYLATION-0.294
- MITOTIC_SPINDLE-0.289
- ANDROGEN_RESPONSE-0.280
- MYC_TARGETS_V2-0.268
- ADIPOGENESIS-0.241
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG490 | — | — | 0.899 |
| 2 | MNG450 | — | — | 0.854 |
| 3 | MNG882 | — | — | 0.845 |
| 4 | MNG1098 | — | — | 0.838 |
| 5 | MNG837 | — | — | 0.833 |
| 6 | SRR12202445 | — | — | 0.833 |
| 7 | MNG1245 | — | — | 0.832 |
| 8 | SRR26320079 | — | — | 0.832 |
| 9 | ULC0454T_S39 | — | cohortMD2 | 0.830 |
| 10 | ERR2278882 | — | — | 0.830 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 17 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ALLOGRAFT_REJECTION | 0.381 | Idelalisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.309 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.275 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.222 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.196 | Cobimetinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.192 | Inavolisib | — uncovered |
| MYOGENESIS | 0.170 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.147 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.140 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.088 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.068 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.032 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.029 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.027 | Inavolisib | — uncovered |
| COAGULATION | 0.018 | Binimetinib | — uncovered |
| P53_PATHWAY | 0.011 | Idelalisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.009 | Idelalisib | — uncovered |