MBCProject_0589_T1A_RNA
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.320
- HEDGEHOG_SIGNALING+0.230
- WNT_BETA_CATENIN_SIGNALING+0.200
- APICAL_SURFACE+0.190
- KRAS_SIGNALING_DN+0.160
- MYOGENESIS+0.090
- UV_RESPONSE_DN+0.090
- BILE_ACID_METABOLISM+0.070
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.020
- COAGULATION+0.000
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.510
- TNFA_SIGNALING_VIA_NFKB-0.480
- MTORC1_SIGNALING-0.430
- OXIDATIVE_PHOSPHORYLATION-0.420
- INFLAMMATORY_RESPONSE-0.390
- APOPTOSIS-0.370
- INTERFERON_GAMMA_RESPONSE-0.340
- PEROXISOME-0.340
- ALLOGRAFT_REJECTION-0.330
- IL6_JAK_STAT3_SIGNALING-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MBCProject_0589_T1_RNA | — | A | 0.911 |
| 2 | d2995480-5ae0-42e1-9a21-25e1435201ee | — | — | 0.897 |
| 3 | MDT-AP-3189 | Med | Medulloblastoma | 0.893 |
| 4 | SRR33346962 | — | — | 0.881 |
| 5 | ERR4976613 | — | D | 0.880 |
| 6 | MNG189 | — | — | 0.874 |
| 7 | BS_YMAJC22S | low-grade glioma | — | 0.873 |
| 8 | SRR1478032 | GTEX | — | 0.872 |
| 9 | e3d71c3f-4e56-45fa-be88-2cf444b70a5c | — | — | 0.870 |
| 10 | MNG584 | — | — | 0.870 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.320 | Cobimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.230 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.200 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.190 | Temsirolimus | — uncovered |
| KRAS_SIGNALING_DN | 0.160 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.090 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.090 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.070 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.020 | Inavolisib | — uncovered |