ERR4976613
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
- overall_survival_months
- 5
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.280
- PANCREAS_BETA_CELLS+0.280
- SPERMATOGENESIS+0.220
- HEDGEHOG_SIGNALING+0.150
- APICAL_SURFACE+0.010
- COAGULATION-0.010
- MYOGENESIS-0.030
- BILE_ACID_METABOLISM-0.050
- APICAL_JUNCTION-0.060
- WNT_BETA_CATENIN_SIGNALING-0.070
Top 10 suppressed
- MYC_TARGETS_V1-0.460
- INTERFERON_ALPHA_RESPONSE-0.450
- OXIDATIVE_PHOSPHORYLATION-0.430
- INTERFERON_GAMMA_RESPONSE-0.380
- PROTEIN_SECRETION-0.380
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.380
- MTORC1_SIGNALING-0.370
- TGF_BETA_SIGNALING-0.370
- ADIPOGENESIS-0.340
- DNA_REPAIR-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR4976605 | — | D | 0.960 |
| 2 | SRR26320081 | — | — | 0.957 |
| 3 | SRR1323130 | GTEX | — | 0.955 |
| 4 | BS_4GTESTSE | Ganglioglioma | — | 0.955 |
| 5 | MDT-AP-3189 | Med | Medulloblastoma | 0.954 |
| 6 | c7d31245-5d71-4a23-8a33-4f83c4718e20 | — | — | 0.954 |
| 7 | SRR934787 | — | — | 0.954 |
| 8 | SRR12696743 | — | — | 0.953 |
| 9 | ERR4976615 | — | D | 0.953 |
| 10 | MNG226 | — | — | 0.952 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.280 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.280 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.220 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.150 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.010 | Temsirolimus | — uncovered |