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AUR-AFUN-TTM1-A-1-0-R-A743-41

· A

91ed94d1-3dfa-5199-a8b6-4c48b5e5a7e9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-A7-A5ZX-01A-12R-A29R-07
breast-umap@18
A0.905
2SRR8613714
breast-umap@18
A0.889
3C3N-01409
lung-landscapes@6
cohortA10.864
4SRR8613705
breast-umap@18
A0.864
5TCGA-D8-A73X-01A-11R-A32P-07
breast-umap@18
B0.860
6TCGA-44-6148-01A-11R-1755-07
lung-landscapes@6
cohortA10.857
7GSM5359413
bladder-landscape@3
0.857
8SAMN03290900
melanoma-umap@29
0.857
9SRR8518225
breast-umap@18
B0.856
10d2995480-5ae0-42e1-9a21-25e1435201ee
colon-landscapes@1
0.854

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 13 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
UV_RESPONSE_DN0.290Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.260Inavolisib— uncovered
NOTCH_SIGNALING0.240Inavolisib— uncovered
MYOGENESIS0.140Inavolisib— uncovered
COAGULATION0.100Binimetinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.090Inavolisib— uncovered
PANCREAS_BETA_CELLS0.070Cobimetinib— uncovered
TGF_BETA_SIGNALING0.070Inavolisib— uncovered
APICAL_JUNCTION0.050Inavolisib— uncovered
KRAS_SIGNALING_DN0.050Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.040Inavolisib— uncovered
BILE_ACID_METABOLISM0.020Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.020Idelalisib— uncovered