SRR8942979
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.520
- KRAS_SIGNALING_DN+0.410
- SPERMATOGENESIS+0.280
- COAGULATION+0.180
- APICAL_SURFACE+0.040
- HEDGEHOG_SIGNALING+0.040
- KRAS_SIGNALING_UP+0.040
- ANGIOGENESIS-0.040
- MYOGENESIS-0.040
- BILE_ACID_METABOLISM-0.060
Top 10 suppressed
- MYC_TARGETS_V2-0.680
- E2F_TARGETS-0.580
- UNFOLDED_PROTEIN_RESPONSE-0.570
- MYC_TARGETS_V1-0.560
- DNA_REPAIR-0.550
- G2M_CHECKPOINT-0.530
- MITOTIC_SPINDLE-0.530
- MTORC1_SIGNALING-0.490
- OXIDATIVE_PHOSPHORYLATION-0.470
- CHOLESTEROL_HOMEOSTASIS-0.460
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR13311172 | — | — | 0.974 |
| 2 | SRR8943002 | — | — | 0.957 |
| 3 | MNG1259 | — | — | 0.955 |
| 4 | SRR1516040 | — | — | 0.955 |
| 5 | MNG597 | — | — | 0.954 |
| 6 | MNG1131 | — | — | 0.954 |
| 7 | SRR1366579 | GTEX | — | 0.950 |
| 8 | SRR12696785 | — | — | 0.950 |
| 9 | msclc569389_S35.txt | — | cohortMD1 | 0.950 |
| 10 | TCGA-CF-A3MF-01A-12R-A21D-07 | — | — | 0.947 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.520 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.410 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.280 | Inavolisib | — uncovered |
| COAGULATION | 0.180 | Binimetinib | — uncovered |
| APICAL_SURFACE | 0.040 | Temsirolimus | — uncovered |
| HEDGEHOG_SIGNALING | 0.040 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.040 | Inavolisib | — uncovered |