SRR8943002
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.400
- KRAS_SIGNALING_DN+0.260
- KRAS_SIGNALING_UP+0.160
- SPERMATOGENESIS+0.160
- HEDGEHOG_SIGNALING+0.130
- COAGULATION+0.070
- ALLOGRAFT_REJECTION-0.020
- MYOGENESIS-0.020
- APICAL_SURFACE-0.060
- INFLAMMATORY_RESPONSE-0.070
Top 10 suppressed
- DNA_REPAIR-0.500
- MITOTIC_SPINDLE-0.470
- E2F_TARGETS-0.460
- G2M_CHECKPOINT-0.460
- UNFOLDED_PROTEIN_RESPONSE-0.440
- MYC_TARGETS_V1-0.430
- MYC_TARGETS_V2-0.430
- PROTEIN_SECRETION-0.420
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.420
- OXIDATIVE_PHOSPHORYLATION-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR8942979 | — | — | 0.957 |
| 2 | TCGA-DK-A1A7-01A-11R-A13Y-07 | — | — | 0.948 |
| 3 | SRR13311172 | — | — | 0.948 |
| 4 | TCGA-CF-A3MF-01A-12R-A21D-07 | — | — | 0.948 |
| 5 | MNG597 | — | — | 0.944 |
| 6 | SRR1516040 | — | — | 0.944 |
| 7 | SRR1394566 | GTEX | — | 0.944 |
| 8 | MNG1133 | — | — | 0.943 |
| 9 | MNG1259 | — | — | 0.942 |
| 10 | MNG1131 | — | — | 0.941 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.400 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.260 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_UP | 0.160 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.160 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.130 | Inavolisib | — uncovered |
| COAGULATION | 0.070 | Binimetinib | — uncovered |