SRR1385080
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.471
- MYOGENESIS+0.249
- PANCREAS_BETA_CELLS+0.233
- SPERMATOGENESIS+0.195
- HEDGEHOG_SIGNALING+0.048
- APICAL_SURFACE+0.021
- ESTROGEN_RESPONSE_LATE+0.008
- ESTROGEN_RESPONSE_EARLY-0.047
- COAGULATION-0.061
- APICAL_JUNCTION-0.102
Top 10 suppressed
- MYC_TARGETS_V1-0.614
- PROTEIN_SECRETION-0.553
- MTORC1_SIGNALING-0.549
- INTERFERON_ALPHA_RESPONSE-0.511
- DNA_REPAIR-0.472
- UNFOLDED_PROTEIN_RESPONSE-0.459
- OXIDATIVE_PHOSPHORYLATION-0.448
- E2F_TARGETS-0.442
- MYC_TARGETS_V2-0.431
- ANDROGEN_RESPONSE-0.428
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1323130 | GTEX | — | 0.979 |
| 2 | SRR602927 | GTEX | — | 0.976 |
| 3 | SRR1406561 | GTEX | — | 0.974 |
| 4 | SRR1366141 | GTEX | — | 0.974 |
| 5 | SRR1336379 | GTEX | — | 0.972 |
| 6 | SRR1432343 | GTEX | — | 0.972 |
| 7 | MNG226 | — | — | 0.971 |
| 8 | 8ad884fa-e426-4bc0-960d-08db42d341da | — | — | 0.964 |
| 9 | SRR1313951 | GTEX | — | 0.960 |
| 10 | c7d31245-5d71-4a23-8a33-4f83c4718e20 | — | — | 0.960 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.471 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.249 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.233 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.195 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.048 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.021 | Temsirolimus | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.008 | Idelalisib | — uncovered |