MNG452
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PEROXISOME+0.146
- PROTEIN_SECRETION+0.131
- INTERFERON_ALPHA_RESPONSE+0.097
- TGF_BETA_SIGNALING+0.093
- DNA_REPAIR+0.072
- MYC_TARGETS_V1+0.068
- NOTCH_SIGNALING+0.034
- HEME_METABOLISM+0.032
- SPERMATOGENESIS+0.019
- WNT_BETA_CATENIN_SIGNALING-0.007
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.464
- TNFA_SIGNALING_VIA_NFKB-0.422
- ANGIOGENESIS-0.406
- PANCREAS_BETA_CELLS-0.351
- HYPOXIA-0.340
- P53_PATHWAY-0.331
- HEDGEHOG_SIGNALING-0.324
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.317
- CHOLESTEROL_HOMEOSTASIS-0.297
- UV_RESPONSE_UP-0.287
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | C3N-00559 | — | cohortA1 | 0.861 |
| 2 | R247 | — | — | 0.834 |
| 3 | C3N-03073 | — | cohortA1 | 0.829 |
| 4 | SJEPD030097_D2.RNA-Seq | EPN | Spinal EPN | 0.828 |
| 5 | SRR650132 | — | — | 0.819 |
| 6 | SRR8613727 | — | D | 0.814 |
| 7 | SRR35579813 | — | B | 0.814 |
| 8 | MDT-AP-0329 | Med | Medulloblastoma | 0.812 |
| 9 | SRR11296802 | — | — | 0.811 |
| 10 | MNG45 | — | — | 0.810 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PEROXISOME | 0.146 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.131 | Remibrutinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.097 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.093 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.072 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.068 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.034 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.032 | Temsirolimus | — uncovered |
| SPERMATOGENESIS | 0.019 | Inavolisib | — uncovered |