SRR8613727
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- NOTCH_SIGNALING+0.180
- HEME_METABOLISM-0.040
- SPERMATOGENESIS-0.050
- WNT_BETA_CATENIN_SIGNALING-0.060
- FATTY_ACID_METABOLISM-0.070
- OXIDATIVE_PHOSPHORYLATION-0.090
- MITOTIC_SPINDLE-0.100
- DNA_REPAIR-0.110
- ANDROGEN_RESPONSE-0.120
- PANCREAS_BETA_CELLS-0.120
Top 10 suppressed
- ANGIOGENESIS-0.620
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.540
- TNFA_SIGNALING_VIA_NFKB-0.460
- MYC_TARGETS_V2-0.450
- CHOLESTEROL_HOMEOSTASIS-0.440
- MTORC1_SIGNALING-0.430
- HYPOXIA-0.410
- INTERFERON_GAMMA_RESPONSE-0.400
- INTERFERON_ALPHA_RESPONSE-0.390
- COAGULATION-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MBCProject_0004_T1_RNA | — | C | 0.921 |
| 2 | SRR23303775 | — | — | 0.919 |
| 3 | C3N-03420 | — | cohortA1 | 0.916 |
| 4 | R247 | — | — | 0.914 |
| 5 | AUR-AFE5-TTM9-A-1-1-R-A742-41 | — | D | 0.905 |
| 6 | SRR11296800 | — | — | 0.904 |
| 7 | SRR607967 | GTEX | — | 0.900 |
| 8 | SRR11296802 | — | — | 0.896 |
| 9 | SRR1364800 | GTEX | — | 0.895 |
| 10 | SRR8943008 | — | — | 0.894 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 1 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| NOTCH_SIGNALING | 0.180 | Inavolisib | — uncovered |