SRR934787
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- overall_survival_months
- 59.526938239159
- age_years
- 57
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.296
- SPERMATOGENESIS+0.267
- APICAL_SURFACE+0.125
- PANCREAS_BETA_CELLS+0.088
- BILE_ACID_METABOLISM+0.049
- COAGULATION-0.047
- WNT_BETA_CATENIN_SIGNALING-0.087
- NOTCH_SIGNALING-0.093
- XENOBIOTIC_METABOLISM-0.141
- HEDGEHOG_SIGNALING-0.165
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.665
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.625
- MYC_TARGETS_V1-0.583
- MTORC1_SIGNALING-0.511
- DNA_REPAIR-0.491
- CHOLESTEROL_HOMEOSTASIS-0.484
- MYC_TARGETS_V2-0.479
- INTERFERON_ALPHA_RESPONSE-0.475
- ADIPOGENESIS-0.474
- P53_PATHWAY-0.465
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_4GTESTSE | Ganglioglioma | — | 0.970 |
| 2 | SRR934856 | — | — | 0.961 |
| 3 | SRR934779 | — | — | 0.960 |
| 4 | SRR12696785 | — | — | 0.956 |
| 5 | ERR4976613 | — | D | 0.954 |
| 6 | ERR4976615 | — | D | 0.953 |
| 7 | SRR934844 | — | — | 0.951 |
| 8 | SRR12696758 | — | — | 0.947 |
| 9 | MDT-AP-3189 | Med | Medulloblastoma | 0.946 |
| 10 | c7d31245-5d71-4a23-8a33-4f83c4718e20 | — | — | 0.946 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.296 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.267 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.125 | Temsirolimus | — uncovered |
| PANCREAS_BETA_CELLS | 0.088 | Cobimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.049 | Inavolisib | — uncovered |