Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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SRR1455060

GTEX

acaf3fec-9400-5f5a-8a12-1bea7027f4d9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.235
  • PANCREAS_BETA_CELLS+0.002
  • SPERMATOGENESIS-0.006
  • G2M_CHECKPOINT-0.045
  • MITOTIC_SPINDLE-0.086
  • E2F_TARGETS-0.093
  • PI3K_AKT_MTOR_SIGNALING-0.099
  • APICAL_SURFACE-0.112
  • APICAL_JUNCTION-0.149
  • UV_RESPONSE_DN-0.151

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.593
  • OXIDATIVE_PHOSPHORYLATION-0.533
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.493
  • TGF_BETA_SIGNALING-0.486
  • INTERFERON_GAMMA_RESPONSE-0.476
  • TNFA_SIGNALING_VIA_NFKB-0.467
  • ANGIOGENESIS-0.444
  • ADIPOGENESIS-0.442
  • APOPTOSIS-0.412
  • FATTY_ACID_METABOLISM-0.409

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR627299
brain-umap@2
GTEX0.976
2SRR627453
brain-umap@2
GTEX0.966
3SRR1471374
brain-umap@2
GTEX0.965
4SRR598009
brain-umap@2
GTEX0.964
5SRR1467813
brain-umap@2
GTEX0.963
6BS_J71N7D09
brain-umap@2
medulloblastoma0.962
7SRR1485789
brain-umap@2
GTEX0.962
8SRR12696758
melanoma-umap@29
0.959
9SRR1436444
brain-umap@2
GTEX0.958
10SRR1439850
brain-umap@2
GTEX0.958

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 2 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.235Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.002Cobimetinib— uncovered